(051) Gut Microbiota and Sexual Desire Disorder in Women

Abstract Introduction Hyposexual desire disorder (HSDD) is a common female sexual health problem. HSDD mainly refers to women's continuous lack of fantasy or for activities, accompanied by obvious personal pain affecting the partnership. In humans, regulated variety neurotransmitters in key areas brain. Norepinephrine, dopamine, melanocortin, oxytocin and vasopressin mediate excitability, while serotonin, opioids, prolactin endogenous cannabinoid system inhibition. may be related neuropsychological state increased inhibition decreased excitation, both. There close relationship between gut microbiota mental neurological diseases. The changes richness diversity affect functions 5-hydroxytryptamine, norepinephrine dopaminergic nervous systems brain, these pathways molecules have been proved closely level human desire. At present, understanding role regulation mechanism limited. Objective order study composition fecal metabolites women, increase possible low intestinal microbiota, this hypothesized that microorganisms patients was different from normal people. Methods We recruited diagnosed women through Case-Control study, performed 16S rRNA sequencing, non targeted LC-MS metabonomics detection SCFAs quantitative explore evaluate differences control group. Results 24 with 22 without history dysfunction (NHSD) were included. gene sequencing 46 samples showed flora higher than those NHSD there significant two groups. genus level, Bifidobacterium, Lactobacillus, Sphingomonas, Phenylbacillus, Corynebacterium some unclassified actinomycetes enriched feces Ruminococcus women. results non-targeted metabolic phenotype. main included histamine, deoxycorticosterone, tryptamine, tyramine, 6-methylquinoline, etc. analysis content butyric acid group significantly Spearman correlation difference groups associated clinical characteristics including FSFI-D score. Conclusions effect characteristic bacteria on function neurotransmitter part pathogenesis HSDD. Further studies bring new theories brain axis. Disclosure No